兔抗人、大、小鼠等活化半胱胺酸蛋白酶蛋白-3***

中文名称：

   兔抗人、大、小鼠等活化半胱胺酸蛋白酶蛋白-3***

英文名称：

   Anti-Caspase-3(Active)

其他名称：

   Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cle***age protease; SCA 1; SCA1; SREBP cle***age activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cle***age activity 1; SCA-1.

产品品牌：

   Pllabs

产品编号：

 PL030081R

产品规格：

  0.1mg/0.2mg

产品包装：

   一支包装（原装进口、进口分装）

​免 疫 原：

   KLH conjugated synthetic peptide derived from human Caspase-3 (Active) N-terminus

***类型：

   Rabbit Polyclonal IgG

背景介绍：

  The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cle***age by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 c***ists of large (17kDa) and ***all (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cle***ed at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cle***es and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 h***e been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cle***age of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Reacts with Caspase-3 subunit p17 and precursor.

应用范围：

Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep               （Please decide the specificity by homology）

更多产品：

 （加拿大PLlabs公司***）

其他产品：

   （华拓生物中文网）